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. Author manuscript; available in PMC: 2009 Sep 25.
Published in final edited form as: Clin Pharmacol Ther. 2007 Sep 19;83(1):160–166. doi: 10.1038/sj.clpt.6100367

Figure 1.

Figure 1

Selected transformation pathways of tamoxifen and the main CYP enzymes involved. The relative contribution of each pathway to the overall oxidation of tamoxifen is shown by the thickness of the arrow, and the principal P450 isoforms responsible are highlighted in larger fonts. Modified in part from Jin, Y. et al. J. Natl. Cancer Inst. 97, 30–39 (2005).