Table II.
Activity for Vorinostat against the PPTP in Vivo Panel
| Xenograft Line |
Histology | KM Estimate of Median Time to Event |
P-value | EFS T/C |
Median Final RTV |
Tumor Volume T/C |
P- value |
Overall Group Response |
T/C Volume Activity |
EFS Activity |
Response Activity |
|---|---|---|---|---|---|---|---|---|---|---|---|
| KT-10 | Wilms | 12.0 | 0.032 | 1.3 | >4 | 0.67 | 0.15 | PD1 | Low | Low | Low |
| KT-11 | Wilms | 17.4 | 0.004 | 1.9 | >4 | 0.34 | <0.001 | PD2 | Int | Low | Int |
| KT-13 | Wilms | 12.8 | 0.197 | 1.3 | >4 | 0.71 | 0.05 | PD1 | Low | Low | Low |
| SK-NEP-1 | Ewing | 11.6 | 0.034 | 1.7 | >4 | 0.61 | 0.03 | PD2 | Low | Low | Int |
| EW5 | Ewing | 13.8 | 0.044 | 1.1 | >4 | 1.02 | 0.50 | PD1 | Low | Low | Low |
| EW8 | Ewing | 15.3 | <0.001 | 1.6 | >4 | 0.57 | 0.00 | PD2 | Low | Low | Int |
| TC-71 | Ewing | 10.4 | 0.143 | 1.8 | >4 | 0.48 | 0.04 | PD2 | Low | Low | Int |
| CHLA258 | Ewing | 10.4 | 0.349 | 1.2 | >4 | 0.90 | 0.37 | PD1 | Low | Low | Low |
| Rh30 | ALV RMS | 20.3 | 0.611 | 1.0 | >4 | 0.84 | 0.97 | PD1 | Low | Low | Low |
| Rh30R | ALV RMS | 20.9 | 0.012 | 1.3 | >4 | 0.63 | 0.04 | PD1 | Low | Low | Low |
| Rh41 | ALV RMS | 19.1 | <0.001 | 1.6 | >4 | 0.56 | <0.001 | PD2 | Low | Low | Int |
| Rh18 | EMB RMS | 19.8 | 0.063 | 1.5 | >4 | 0.57 | 0.01 | PD1 | Low | Low | Low |
| Rh36 | EMB RMS | 24.4 | 0.005 | 1.4 | >4 | 0.89 | 0.36 | PD1 | Low | Low | Low |
| BT-28 | Medulloblastoma | 5.7 | 0.052 | 1.2 | >4 | 0.82 | 0.08 | PD1 | Low | Low | Low |
| BT-45 | Medulloblastoma | 16.6 | 0.026 | 1.3 | >4 | 0.84 | 0.10 | PD1 | Low | Low | Low |
| BT-46 | Medulloblastoma | 7.3 | 0.625 | 1.2 | >4 | 0.91 | 0.58 | PD1 | Low | Low | Low |
| BT-44 | Ependymoma | 26.1 | 0.357 | 0.7 | >4 | 1.61 | 0.02 | PD1 | Low | Low | Low |
| BT-39 | Glioblastoma | 10.0 | 0.918 | 1.0 | >4 | 1.04 | 0.74 | PD1 | Low | Low | Low |
| D645 | Glioblastoma | 8.6 | 0.891 | 1.0 | >4 | 1.03 | 0.53 | PD1 | Low | Low | Low |
| D456 | Glioblastoma | 6.0 | 0.872 | 1.1 | >4 | 0.90 | 0.66 | PD1 | Low | Low | Low |
| NB-SD | Neuroblastoma | > EP | 0.225 | > 1.5 | 3.0 | 1.18 | 1.00 | PD2 | Low | NE | Int |
| NB-1771 | Neuroblastoma | 35.2 | <0.001 | 1.4 | >4 | 0.31 | <0.001 | PD1 | Int | Low | Low |
| NB-1691 | Neuroblastoma | 10.7 | 0.076 | 1.1 | >4 | 0.85 | 0.06 | PD1 | Low | Low | Low |
| NB-EBc1 | Neuroblastoma | 10.4 | 0.012 | 1.6 | >4 | 0.69 | 0.02 | PD2 | Low | Low | Int |
| CHLA-79 | Neuroblastoma | 27.5 | 0.041 | 1.1 | >4 | 0.78 | 0.48 | PD1 | Low | Low | Low |
| NB-1643 | Neuroblastoma | 12.9 | 0.021 | 1.3 | >4 | 0.48 | 0.00 | PD1 | Low | Low | Low |
| OS-1 | Osteosarcoma | 34.5 | 0.062 | 1.1 | >4 | 0.77 | 0.10 | PD1 | Low | Low | Low |
| OS-17 | Osteosarcoma | 24.2 | 0.004 | 1.8 | >4 | 0.49 | <0.001 | PD2 | Low | Low | Int |
| OS-9 | Osteosarcoma | > EP | 0.002 | > 1.6 | 3.2 | 0.67 | 0.03 | PD2 | Low | NE | Int |
| OS-31 | Osteosarcoma | 21.1 | 0.003 | 1.3 | >4 | 0.58 | 0.01 | PD1 | Low | Low | Low |
| ALL-2 | ALL B-precursor | 9.8 | 0.269 | 0.8 | >25 | . | PD1 | Low | Low | ||
| ALL-3 | ALL B-precursor | 8.2 | 0.396 | 0.8 | >25 | . | PD1 | Low | Low | ||
| ALL-4 | ALL B-precursor | 2.3 | 0.731 | 1.3 | >25 | . | PD1 | Low | Low | ||
| ALL-7 | ALL B-precursor | 2.0 | 1.000 | 1.0 | >25 | . | PD1 | Low | Low | ||
| ALL-8 | ALL T-cell | 6.7 | 0.519 | 1.1 | >25 | . | PD1 | Low | Low | ||
| ALL-16 | ALL T-cell | 15.8 | 0.072 | 1.4 | >25 | . | PD1 | Low | Low | ||
| ALL-17 | ALL B-precursor | 2.0 | 1.000 | 1.0 | >25 | . | PD1 | Low | Low | ||
| ALL-19 | All B-precursor | 1.0 | 0.674 | 1.0 | >25 | . | PD1 | Low | Low |