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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Hypertension. 2009 Jun 8;54(2):338–344. doi: 10.1161/HYPERTENSIONAHA.108.127928

Figure 2.

Figure 2

Endothelium-dependent and endothelium-independent vasorelaxation in wild-type (wt) or transgenic mice overexpressing human thioredoxin-2 (TghTrx2) with or without chronic angiotensin II (Ang II) infusion: Aortic segments (3mm) were mounted in isolated organ chamber baths and basal tension adjusted to 1 gram. Vascular relaxations to increasing concentrations of acetylcholine (A) and the nitric oxide donor, DEA-NONOate (B) were measured after preconstriction with PGF2α. The contractile response to increasing concentration of phenylephrine (Pe) is shown in C; previous addition of L-NAME (100µmol/, D) strikingly increased this response in all groups. Mean ± SEM, n = 4–7.