Fig. 4.
Effect of IL-18BP MSC on left ventricular infarct size after LAD ligation. Ten minutes after ligation, a solution of 100 μL PBS (vehicle), WT MSCs, or IL-18BP MSCs (1 × 107 cells/mL) was injected into the myocardium at two sites around the infarct border zone. (A) Representative transverse sections of rat hearts at 28 days post-LAD ligation in sham, ischemia + vehicle, ischemia + WT MSC and ischemia + IL-18BP MSC groups. The non-ischemic area (blue region) was stained with 2% Evans Blue Dye. The at-risk area (red region) was stained with 1% TTC. The infarct area (pale/white zone) did not stain with Evans or TTC. (B) The percentage of the infarct area weight to the ischemic area weight is represented. The results are the mean ± SEM. (n = 6 rats/group; *, P < 0.05 vs. ischemia + vehicle; #, P < 0.05 vs. ischemia + WT MSC).