Table 1.

Clinical features of PGRN (+) and (−) subjects

	Sex	Age at onset	Illness duration (years)	STMS at scan	*Diagnosis at the time of Scan	Prominent symptoms up to the time of MRI scan	Symptoms present over entire disease course (+ = present, 0 = absent)
							Parkinsonism	Language	Behavior
PGRN (−)
1	F	64	13	25	bvFTD	Personality change, apathy, loss of interest	0	0	+
2	F	62	8	34	bvFTD	Anhedonic, lack of initiative, poor judgment	0	0	+
3	M	45	13	26	bvFTD	Personality change, withdrawn, lack of initiative	0	0	+
4	F	68	3	NA	CBS	Parkinsonism, L>R limb apraxia	+	0	0
5	F	64	6	34	bvFTD	Changes in behavior and personality	+	0	+
6	M	51	1	30	bvFTD	Executive dysfunction, decreased personal hygiene, inappropriate laughter, compulsive behaviors	+	+	+
7	F	59	7	26	SD	Difficulty with naming of people and objects, and circumlocutions, behavioral changes	0	+	+
8	F	77	6	31	bvFTD	Personality change, executive dysfunction, & paranoia	0	0	+
PGRN (+)
9	M	69	7	28	bvFTD	Executive dysfunction, loss of attention, & memory loss	+	+	+
10	M	60	8	31	bvFTD	Personality change, executive dysfunction & memory loss	+	+	+
11	F	52	5	23	bvFTD	Personality change, executive dysfunction, abulia, memory loss, and decrease word output & fluency	+	+	+
12	M	49	6	27	CBS	Parkinsonism, L>R limb apraxia	+	+	0
13	M	56	7	34	bvFTD	Personality change	+	0	+
14χ	F	56	7	32	bvFTD	Personality change, executive dysfunction & memory loss	+	+	+
15χ	F	61	NA	NA	SD	Difficulty with naming of people, places, and things and comprehension problems	0	+	0
16	F	56	NA	22	bvFTD	Executive dysfunction	+	+	+

STMS = Short Test of Mental Status Score

^*Diagnosis based on Consensus criteria¹,²²

^χSubjects still alive

Using Fishers Exact test p =0.05 for parkinsonism PGRN (−) v PGRN (+) (30% vs. 90%) and P = 0.02 for language (20% vs. 90%) using a one tail test (assuming that the feature would be more frequent in the PGRN (+) group).