Fig. 1.

Vestibulomotor performance measured as latency of animals falling from a rotating rod (A). Data plotted as mean ± SEM in seconds. Animals treated with COG1410 showed significant improvement of vestibule-motor performance at 5 and 7 days vs. vehicletreated MCAO-only animals (*P < 0.05), whereas MCAO-only animals lagged from shams until 14 day (^#P < 0.05). In the testing of ketamine-induced asymmetry (B), rotational behavior of COG1410-treated animals was significantly more symmetrical compared with MCAO-only animals (*P < 0.05), which showed asymmetrical behavior vs. shams over the whole testing period (^#P < 0.05). Data are plotted as mean ± SEM percentage of ipsilateral-to-lesion rotations. Stroke-associated spontaneous asymmetry in the rotational behavior, measured in the open field (C), was not evident in COG1410-treated animals compared with shams, whereas MCAO-only animals showed increased amount of rotations ipsilateral to the lesion side vs. COG1410-treated animals (*P < 0.05) and sham animals (_#P < 0.05). Data are presented as mean ± SEM number of ipsilateral rotations.