Table 1. Results of single SNP TDT and case/pseudo–control analysis in Caucasian families for the 14 haplotype-tagging SNPs genotyped across SHANK3.

		Single SNP TDT		Case/pseudo control analysis
Tagging SNP	SNPs capured	Global χ2 (1 d.f.)	P-value	OR for allele 2 vs 1	95% CI	P-value
rs9616915	rs9616915, rs9616913, rs9628185	0.04	0.84	1.02	(0.85–1.22)	0.84
rs2341009	rs2341009	1.44	0.23	1.14	(0.92–1.41)	0.23
rs2341010	rs1001469, rs2341010	0.41	0.52	1.08	(0.86–1.35)	0.53
rs2341011	rs736334, rs2341011, rs9616816	1.81	0.18	0.86	(0.69–1.07)	0.18
rs739365	rs739365	1.11	0.29	0.90	(0.75–1.09)	0.29
rs5770992	rs5770992	1.81	0.18	0.79	(0.57–1.11)	0.18
rs6010060	rs6010060	0.39	0.53	0.89	(0.63–1.27)	0.54
rs2040487	rs2040487	1.35	0.28	0.90	(0.75–1.09)	0.28
rs6010061	rs6009951, rs6010061	1.35	0.25	0.90	(0.75–1.07)	0.25
rs2106111	rs2106111	0.27	0.60	0.95	(0.80–1.14)	0.60
rs6010063	rs6010063, rs6010065	0.47	0.49	1.06	(0.89–1.27)	0.49
rs715586	rs715586	0.03	0.87	0.98	(0.76–1.26)	0.87
rs8137951	rs8137951	0.48	0.49	0.93	(0.76–1.14)	0.49
rs756638	rs756638	0.22	0.64	1.05	(0.86–1.28)	0.64
rs739365, rs6010061	rs5770820	0.48	0.49

CI, confidence interval; df, degrees of freedom; OR, odds ratio.

The SNPs captured by the tagging SNPs are also shown.