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. 2009 Sep 9;106(38):16481–16486. doi: 10.1073/pnas.0902833106

Fig. 1.

Fig. 1.

Dendritic mRNA localization of BDNF-GFP chimaeras. (A) In situ labeling of neurons transfected with GFP or BDNF-GFP transcripts. Arrows show the MDDL. (Scale bar, 10 μm.) Densitometric traces of linearized dendrites (ImageJ-straighten) are shown. (B) rEx2B-CDS-, rEx2C-CDS-, rEx6-CDS-, and rCDS-GFP show distal dendritic localization and comparable RDF. rEx1- and rEx4-CDS-GFP display proximal dendritic localization with lower RDF values than rCDS-GFP (***, P < 0.001). Depolarization had no effects, except for CaMKII-GFP (***, P < 0.001). (C) Densitometric analysis shows a rapid decline to background for rEx1-CDS-GFP and rEx4-CDS-GFP while the other chimaeric mRNAs remained elevated at 35–45 or 65–75 μm from the soma (***, P < 0.001 vs. rEx1-CDS-GFP). Error bars, SEM.

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