Fig. 6.

Proposed model of BDNF mRNAs sorting mechanisms. Multiple 5′ UTR sequences with either inhibitory or permissive targeting properties determine transcript-selective sorting. Translocation to dendrites is mediated by constitutive dendritic targeting signals in the CDS that require binding of the translin/trax complex at the G178-G196 residues. The 3′ UTR region(s) contain inducible dendritic targeting signals that respond to KCl and BDNF and cooperate with the constitutive signals in the CDS mediated by the translin/trax complex.