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. 2009 Sep 10;106(38):16434–16445. doi: 10.1073/pnas.0905696106

Fig. 3.

Fig. 3.

Changes in cell-cycle gene expression in embryonic LgDel cortex. (A) Six 22q11 putative cell-cycle genes show diminished expression by ≈50% (*, P ≤ 0.05; **, P ≤ 0.001) relative to WT E13.5 cortex. (B) Quantitative PCR verifies that three cell-cycle gene transcripts are diminished by ≈50% (*, P ≤ 0.05) in E13.5 LgDel cortex relative to WT as suggested by cell-cycle array. (C–E) Protein products of these three genes are detected in cells that also express Cdc45l, PH3, or Tbr2. (C) Sestrin2 (Left), colabeled with Cd45l (Center), or PH3 (Right). (D) CyclinD1 in E13.5 cortex (Left), colabeled with Cdc45l (Center), or Tbr2 (Right). (E) E2f2 in E13.5 cortex (Left), colabeled with Cdc45l (Center), or Tbr2 (Right).