Table 2.
Significance of the fixed effects (IGF-1, Compression, Time) from the mixed-effects model of gene expression, and for interactions (IGF-1 and Compression; Time and Compression)
| IGF-1 | 50%-Compression | Time | IGF-1 and 50%-Compression | Time and 50%-Compression | |
|---|---|---|---|---|---|
| TGF-B | - | < 0.0001 | < 0.0001 | - | 0.0008 |
| TNF-a | < 0.0001 | < 0.0001 | 0.0419 | 0.0010 | - |
| IL-6 | - | - | - | - | - |
| IL-4 | - | - | - | - | - |
| IL-1 | < 0.0001 | < 0.0001 | - | < 0.0001 | - |
| IGF-2 | < 0.0001 | < 0.0001 | - | 0.0002 | - |
| IGF-1 | < 0.0001 | < 0.0001 | < 0.0001 | 0.0192 | 0.0004 |
| c-Jun | < 0.0001 | < 0.0001 | < 0.0001 | 0.0058 | 0.0001 |
| c-Fos | < 0.0001 | < 0.0001 | < 0.0001 | 0.0002 | 0.0010 |
| Sox-9 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | 0.0224 |
| HSP90 | < 0.0001 | < 0.0001 | - | < 0.0001 | - |
| Txnip | < 0.0001 | < 0.0001 | < 0.0001 | 0.0015 | 0.0138 |
| TIMP-3 | 0.0005 | < 0.0001 | < 0.0001 | - | 0.0001 |
| TIMP-2 | 0.0156 | < 0.0001 | < 0.0001 | - | 0.0038 |
| TIMP-1 | - | - | - | - | - |
| ADAMTS-5 | - | 0.0083 | 0.0019 | - | - |
| MMP-13 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | 0.0014 |
| MMP-3 | < 0.0001 | < 0.0001 | < 0.0001 | 0.0031 | < 0.0001 |
| MMP-1 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | 0.0011 |
| Link | < 0.0001 | < 0.0001 | - | < 0.0001 | - |
| Fibronectin | - | < 0.0001 | < 0.0001 | - | 0.0104 |
| Collagen II | < 0.0001 | < 0.0001 | < 0.0001 | 0.02 | < 0.0001 |
| Aggrecan | < 0.0001 | < 0.0001 | - | < 0.0001 | - |