Table 2.
P-values of top 10 SNPs by LME minimum p-value ranking and then subsequently by SOLAR analyses for each of the two examination.
|
LME Analysis |
Solar Analysis |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chro- mosome |
Physical Position |
cM | P recessive |
P additive |
P dominant |
lowest P | P value ranking |
P recessive |
P additive |
P dominant |
lowest P | P value ranking |
| Examination 1 | |||||||||||||
| rs9323037 | 14 | 40501442 | 44.774 | <E-10 | 0.0119618 | 0.02237731 | <E-10 | 1 | 0.34601 | 0.04496 | 0.02305 | 0.02305 | 49 |
| rs1903937 | 12 | 43807754 | 56.322 | 4.191E-05 | 4.214E-07 | 2.9055E-05 | 4.214E-07 | 2 | 0.00023 | 6.36E-06 | 0.0003 | 6.36E-06 | 2 |
| rs10508059 | 13 | 100730832 | 84.627 | 0.0002288 | 1.281E-06 | 2.0363E-05 | 1.281E-06 | 3 | 0.00295 | 3.64E-05 | 0.00025 | 3.64E-05 | 7 |
| rs10516862 | 4 | 91354349 | 100.024 | 0.0131153 | 2.383E-06 | 0.10268287 | 2.383E-06 | 4 | 0.63002 | 0.249626 | 0.20494 | 0.204938 | 50 |
| rs998358 | 8 | 123842133 | 130 | 2.931E-06 | 1.746E-05 | 0.13625395 | 2.931E-06 | 5 | 0.10659 | 0.000192 | 0.00011 | 0.000108 | 21 |
| rs1596516 | 12 | 39490195 | 55.29 | 0.0232866 | 6.309E-05 | 5.8415E-06 | 5.842E-06 | 6 | 3.2E-05 | 0.001041 | 0.17783 | 3.17E-05 | 6 |
| rs281877 | 7 | 131278723 | 136.647 | 6.161E-06 | 0.0166819 | 0.1893402 | 6.161E-06 | 7 | 6.4E-05 | 0.012772 | 0.12514 | 0.000064 | 13 |
| rs1113193 | 2 | 234351137 | 243.308 | 0.0006329 | 8.099E-06 | 0.00012286 | 8.099E-06 | 8 | 0.00271 | 9.33E-06 | 7.7E-05 | 9.33E-06 | 3 |
| rs10492939 | 1 | 3326028 | 3.391 | 9.12E-06 | 0.0032361 | 0.16025649 | 9.12E-06 | 9 | 0.00011 | 0.011897 | 0.27678 | 0.000112 | 22 |
| rs9321588 | 6 | 137487052 | 138.019 | 0.6699534 | 0.0127276 | 9.7611E-06 | 9.761E-06 | 10 | 2.1E-05 | 0.028799 | 0.93903 | 2.11E-05 | 4 |
| Examination 2 | |||||||||||||
| rs1113193 | 2 | 234351137 | 243.31 | 0.0345571 | 1.377E-08 | 7.485E-07 | 1.377E-08 | 1 | 0.084459 | 2.48E-05 | 1.68E-05 | 1.68E-05 | 2 |
| rs2269337 | 9 | 130602238 | 144.16 | no converge | 7.242E-08 | 0.0011683 | 7.242E-08 | 2 | 0.012702 | 0.002836 | 0.013068 | 0.002836 | 45 |
| rs618171 | 1 | 215537693 | 239.06 | 1.997E-07 | 0.0493516 | 0.5044529 | 1.997E-07 | 3 | 0.01397 | 0.126232 | 0.583849 | 0.01397 | 48 |
| rs434310 | 6 | 95061282 | 102.81 | 7.412E-05 | 6.592E-07 | 2.328E-05 | 6.592E-07 | 4 | 0.002277 | 1.63E-05 | 0.000132 | 1.63E-05 | 1 |
| rs233818 | 4 | 103561912 | 107.95 | 0.1167418 | 0.0078786 | 8.359E-07 | 8.359E-07 | 5 | 0.035446 | 0.071176 | 0.241546 | 0.035446 | 50 |
| rs9304554 | 18 | 26099175 | 56.71 | 0.0017456 | 1.054E-06 | 1.938E-06 | 1.054E-06 | 6 | 0.002777 | 0.000215 | 0.00168 | 0.000215 | 30 |
| rs1477627 | 11 | 97005057 | 94.029 | 1.406E-06 | 8.673E-05 | 0.4790098 | 1.406E-06 | 7 | 0.771445 | 0.009052 | 0.000352 | 0.000352 | 36 |
| rs1413754 | 6 | 131192319 | 128.93 | 1.452E-06 | 5.857E-05 | 0.0139882 | 1.452E-06 | 8 | 2.32E-05 | 0.000486 | 0.039586 | 2.32E-05 | 5 |
| rs4849360 | 2 | 111532102 | 121.99 | 0.6357593 | 0.1239215 | 1.743E-06 | 1.743E-06 | 9 | 0.005472 | 0.303775 | 0.782526 | 0.005472 | 47 |
| rs756418 | 4 | 11224236 | 23.177 | 0.2779108 | 4.158E-06 | 1.841E-06 | 1.841E-06 | 10 | 0.322777 | 3.72E-05 | 2.46E-05 | 2.46E-05 | 6 |
An extended list with the top 50 SNPs is provided in the Supplementary Tables 1 and 2.
Grey shaded p-values are those with genome-wide significance (p < 0.05/71937 quality-controlled SNPs = <6.95×10−7).