Table 2.

Characteristics of non-Ashkenazi Jewish families^*

	All Families (n = 136)	BRCA1 Point Mutation Positive Families (n = 21)	BRCA2 Point Mutation Positive Families (n = 15)	BRCA1 Genomic Rearrangement Positive Families (n = 7)	BRCA2 Genomic Rearrangement Positive Families (n = 1)	All Mutation Positive Families (n = 44)	All Mutation Negative Families (n = 92)	p value†
Familial Characteristics
Any Breast Cancer (%)	134 (99)	21 (100)	15 (100)	7 (100)	1 (100)	44 (100)	90 (98)	0.55
Breast Cancer <50 y (%)	130 (96)	20 (95)	15 (100)	7 (100)	1 (100)	43 (98)	87 (95)	0.55
Br/Ov Cancer in the same individual (%)	22 (16)	6 (29)	4 (27)	1 (14)	0	11 (25)	11 (12)	0.05
Any Ovarian Cancer (%)	63 (46)	14 (67)	8 (53)	4 (57)	1 (100)	27 (61)	36 (39)	0.02
Male Breast Cancer (%)	9 (7)	1 (5)	1 (6)	0	1 (100)	3 (7)	6 (7)	>0.99
Pancreatic Cancer (%)	9 (7)	1 (5)	5 (33)	0	0	6 (14)	3 (3)	0.03
Prostate Cancer (%)	26 (19)	7 (33)	3 (9)	2 (29)	1 (100)	13 (29)	13 (14)	0.04
Proband Characteristics
Breast Cancer Only (%)	90 (66)	9 (43)	10 (67)	4 (57)	0	23 (52)	67 (73)	0.02
Bilateral Breast Cancer (%)	15 (11)	4 (19)	1 (7)	2 (29)	1 (100)	8 (18)	7 (8)	0.08
Ovarian Cancer Only (%)	13 (10)	3 (14)	1 (7)	1 (14)	0	5 (11)	8 (9)	0.75
Br/Ov Cancer in the same individual (%)	13 (10)	4 (19)	2 (13)	0	0	6 (14)	7 (8)	0.34
Male Breast Cancer (%)	5 (4)	1 (5)	1 (7)	0	0	2 (5)	3 (3)	>0.99
Breast Cancer Average Age Dx	43.1	40.4	43.5	35.7	---	40.8	44.0	0.14‡
Ovarian Cancer Average Age Dx	57.5	51	59	---	---	53.7	60.3	0.57

^*includes up to fourth degree relatives

^†comparison of all mutation positive and negative families using two-tailed Fisher Exact test

^‡comparison of average age of diagnoses using Krushal Wallis test