Skip to main content
. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: Ann Biomed Eng. 2008 Jan 11;36(4):534–544. doi: 10.1007/s10439-007-9429-0

FIGURE 2.

FIGURE 2

Passing RBCs “bounce” rolling leukocytes against the endothelium. Our simulations estimate the forces as RBCs interact with rolling WBCs. The normal force is first negative (directed toward the surface) and then positive (directed away from the surface). By pushing the rolling cell against the endothelium, RBCs likely encourage penetration of microvilli through the glycocalyx and engagement of adhesion molecules. Note also that the tangential force is enhanced, encouraging rolling, except where adhesion molecule density is sufficiently high (reproduced with permission from Ref. 50).