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. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: Int J Biochem Cell Biol. 2007 Apr 22;39(7-8):1349–1357. doi: 10.1016/j.biocel.2007.04.010

Fig. 1. Induction, transcription, and activation of VEGFA.

Fig. 1

a, VEGFA gene transcription is induced by various extra- and intracellular signals, which ultimately target the regulatory elements within the VEGFA promoter region. b, alternative splicing of VEGFA transcript gives rise to VEGFA isoforms/polypeptides with disparate solubilities. c, proteolysis of matrix-bound VEGFA polypeptides releases bioactive fragments.