Table 2.
Functional Classification of T. cruzi Proteins Extracted with Triton X-114
| Functional Category | Metacyclic Trypomastigote N (%)a | Epimastigote N (%)a |
|---|---|---|
| Host-Parasite Relationship (surface proteins) | 39 (39.8%) | 6 (2.1%) |
| Cellular Communication and Signal Transduction | 11 (11.2%) | 20 (7.1%) |
| Intermediate Metabolism and Bioenergetics | 11 (11.2%) | 71 (25.4%) |
| Bioenergetics and Biological Oxidations | 7 | 19 |
| Lipid Metabolism | 2 | 11 |
| Amino Acid Metabolism | 1 | 18 |
| Carbohydrate Metabolism | 0 | 8 |
| Transporters | 1 | 15 |
| Protein Metabolism | 8 (8.2%) | 48 (17.1%) |
| Proteolysis/Peptidolysis | 6 | 21 |
| Protein Folding | 2 | 20 |
| Vesicular Trafficking | 0 | 7 |
| Structural Proteins and Cellular Dynamics | 4 (4.1%) | 17 (6.1%) |
| Stress Response and Cell Defense | 2 (2.0%) | 10 (3.6%) |
| Transcription, Translation and DNA Repair | 0 | 23 (8.2%) |
| Hypothetical Proteins b | 23 (23.5%) | 85 (30.4%) |
| Total | 98 (100%) | 280 (100%) |
a
Number and percentage of proteins.
b
Hypothetical proteins conservedly encoded in the genomes of TriTryps (T. cruzi, T. brucei, and Leishmania major).61