Figure 3.

(A) Mean water consumption during the habituation phase for all F344 and LEW animals prior to aversion conditioning with heroin. LEW animals consumed more water on each day of this phase, except for Day 7 when the consumption by the strains was equivalent. Note: some SE bars fall within the symbol on graph. (B) Mean saccharin consumption across conditioning trials for all F344 (left panel) and LEW (right panel) animals receiving varying doses of heroin or vehicle during aversion conditioning. * denotes consumption by vehicle groups (F344 and LEW) significantly greater than all F344 animals receiving heroin. + indicates saccharin consumption by the vehicle groups (F344 and LEW) significantly greater than LEW animals conditioned with 10 mg/kg heroin. # indicates that the LEW animals conditioned with 3.2 and 5.6 mg/kg consumed significantly more saccharin than all F344 animals conditioned with heroin (3.2, 5.6, and 10 mg/kg). † indicates a significant strain difference in saccharin consumption with all LEW animals conditioned with heroin (3.2, 5.6, and 10 mg/kg) drinking more saccharin than all F344 animals conditioned with heroin. Note: some SE bars fall within the symbol on the graph. (C) Percent saccharin consumption (left panel) and total fluid consumption (right panel) for the first (top) and second (bottom) two-bottle aversion test for all animals conditioned with varying doses of heroin or vehicle. *denotes significant difference from vehicle groups. + denotes significant strain differences at a specific dose of heroin.