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. 2000 Nov 18;321(7271):1255–1259. doi: 10.1136/bmj.321.7271.1255

Table 3.

Adjusted relative risk (95% confidence interval) for adverse maternal outcomes according to interpregnancy interval in cohort of 456 889 Latin American and Caribbean parous women delivering singleton infants, 1985-97*

Outcome Interpregnancy interval (months)
0-5 6-11 12-17 18-23 24-59 ⩾60
Pre-eclampsia 1.00 (0.93 to 1.07) 0.98 (0.88 to 1.08) 1.03 (0.93 to 1.14) 1.0 1.06 (0.96 to 1.18) 1.83 (1.72 to 1.94)
Eclampsia 1.12 (0.63 to 2.29) 1.04 (0.68 to 1.43) 0.97 (0.78 to 1.19) 1.0 1.22 (0.84 to 2.33) 1.80 (1.38 to 2.32)
Third trimester bleeding 1.73 (1.42 to 2.24) 1.03 (0.91 to 1.16) 1.01 (0.88 to 1.14) 1.0 1.04 (0.96 to 1.14) 1.12 (1.00 to 1.24)
Premature rupture of membranes 1.72 (1.53 to 1.93) 1.04 (0.96 to 1.12) 1.02 (0.93 to 1.12) 1.0 1.08 (0.98 to 1.19) 1.03 (0.93 to 1.14)
Postpartum haemorrhage 0.94 (0.76 to 1.13) 0.96 (0.87 to 1.06) 0.98 (0.90 to 1.06) 1.0 0.95 (0.86 to 1.04) 0.91 (0.78 to 1.04)
Puerperal endometritis 1.33 (1.22 to 1.45) 1.04 (0.94 to 1.14) 1.08 (1.00 to 1.17) 1.0 0.99 (0.94 to 1.04) 1.04 (0.94 to 1.15)
Gestational diabetes mellitus 1.02 (0.71 to 1.35) 0.95 (0.84 to 106) 0.91 (0.69 to 1.14) 1.0 1.03 (0.83 to 1.23) 1.25 (0.88 to 1.63)
Anaemia 1.30 (1.18 to 1.43) 1.03 (0.95 to 1.12) 1.02 (0.96 to 1.09) 1.0 1.04 (0.99 to 1.10) 1.01 (0.97 to 1.05)
Maternal death 2.54 (1.22 to 5.38) 1.11 (0.53 to 2.28) 1.03 (0.56 to 2.22) 1.0 1.14 (0.63 to 2.41) 1.07 (0.71 to 2.71)
*

Adjusted for maternal age, No of previous deliveries, history of miscarriage, stillbirth and early neonatal death, previous caesarean delivery, marital status, education, cigarette smoking, body mass index before pregnancy, trimester during which prenatal care was started, No of prenatal care visits, geographic area, hospital type, and year of delivery. Pre-eclampsia, eclampsia, gestational diabetes mellitus, and third trimester bleeding were also adjusted for history of chronic hypertension. 

Reference group.