Table 3.
Gender stratified unadjusted and admixture adjusted genotypic P-values for the significantly associated SNPs with T2DM-ESRD
| a.Females | ||||||||
|---|---|---|---|---|---|---|---|---|
| Marker | Physical Position* |
Location | Dominant P-value |
Dominant Admixture- Adjusted P-value |
Additive P-value |
Additive Admixture- Adjusted P-value |
Recessive P-value |
Recessive Admixture- Adjusted P-value |
| rs866457 | 152074526 | 5′ UTR | 0.018 | 0.096 | 0.006 | 0.041 | 0.036 | 0.087 |
| rs1999805 | 152160477 | 5′ UTR | 0.999 | 0.814 | 0.214 | 0.285 | 0.030 | 0.033 |
| rs1415193 | 152184751 | 5′ UTR | 0.047 | 0.268 | -- | -- | -- | -- |
| rs2504065 | 152187280 | 5′ UTR | 0.705 | 0.713 | 0.184 | 0.141 | 0.045 | 0.022 |
| rs1285057 | 152195905 | 5′ UTR | 0.959 | 0.513 | 0.482 | 0.821 | 0.043 | 0.040 |
| rs11964281 | 152213556 | Promoter | 0.002 | 0.004 | -- | -- | -- | -- |
| rs2077647 | 152221190 | Exon 1 | 0.044 | 0.076 | 0.072 | 0.112 | 0.384 | 0.433 |
| rs11155818 | 152276243 | Intron 2 | 0.038 | 0.073 | -- | -- | -- | -- |
| rs1033182 | 152287147 | Intron 2 | 0.027 | 0.196 | -- | -- | -- | -- |
| rs3020317 | 152370854 | Intron 4 | 0.036 | 0.055 | 0.013 | 0.022 | 0.045 | 0.064 |
| rs985192 | 152375591 | Intron 4 | 0.044 | 0.065 | 0.009 | 0.014 | 0.015 | 0.022 |
| rs3020403 | 152387828 | Intron 4 | 0.031 | 0.167 | -- | -- | -- | -- |
| rs726283 | 152395122 | Intron 4 | 0.004 | 0.033 | -- | -- | -- | -- |
| rs7754762 | 152403650 | Intron 4 | 0.111 | 0.203 | 0.026 | 0.073 | 0.032 | 0.082 |
| rs722208 | 152414998 | Intron 4 | 0.0006 | 0.002 | 0.009 | 0.030 | 0.651 | 0.925 |
| rs1569788 | 152420729 | Intron 4 | 0.0007 | 0.003 | 0.008 | 0.026 | 0.587 | 0.813 |
| rs9340969 | 152424243 | Intron 4 | 0.0007 | 0.003 | 0.006 | 0.022 | 0.511 | 0.724 |
| rs9340973 | 152424810 | Intron 4 (Boundary) | 0.043 | 0.069 | -- | -- | -- | -- |
| rs7755185 | 152431728 | Intron 5 | 0.135 | 0.169 | 0.024 | 0.040 | 0.028 | 0.046 |
| rs2207232 | 152432401 | Intron 5 | 0.008 | 0.008 | -- | -- | -- | -- |
| rs3020411 | 152435876 | Intron 5 | 0.009 | 0.033 | 0.003 | 0.014 | 0.028 | 0.074 |
| rs3020422 | 152440871 | Intron 5 | 0.007 | 0.026 | 0.002 | 0.012 | 0.028 | 0.074 |
| rs3020432 | 152450040 | Intron 5 | 0.007 | 0.026 | 0.002 | 0.012 | 0.028 | 0.074 |
| rs9371573 | 152452833 | Intron 5 | 0.007 | 0.026 | 0.002 | 0.011 | 0.020 | 0.063 |
| rs3020364 | 152459231 | Intron 5 | 0.002 | 0.007 | 0.002 | 0.010 | 0.082 | 0.184 |
| rs6914073 | 152465351 | Intron 5 | 0.040 | 0.075 | 0.174 | 0.332 | 0.987 | 0.717 |
| rs1884152 | 152469293 | Intron 5 | 0.022 | 0.047 | 0.100 | 0.217 | 0.831 | 0.873 |
| rs2273207 | 152474439 | Intron 6 (Boundary) | 0.003 | 0.005 | -- | -- | -- | -- |
| rs3778089 | 152485874 | Intron 6 | 0.011 | 0.036 | 0.003 | 0.014 | 0.021 | 0.058 |
| rs12180788 | 152486892 | Intron 6 | 0.012 | 0.039 | 0.003 | 0.014 | 0.020 | 0.056 |
| rs12181050 | 152489247 | Intron 6 | 0.012 | 0.039 | 0.004 | 0.018 | 0.029 | 0.076 |
| rs3822990 | 152498078 | Intron 6 | 0.012 | 0.022 | -- | -- | -- | -- |
| rs3778090 | 152500141 | Intron 6 | 0.001 | 0.002 | -- | -- | -- | -- |
| rs750686 | 152500239 | Intron 6 | 0.017 | 0.053 | 0.022 | 0.064 | 0.219 | 0.321 |
| rs1543403 | 152520817 | 3′ UTR | 0.174 | 0.199 | 0.677 | 0.658 | 0.035 | 0.038 |
| b.Males | ||||||||
|---|---|---|---|---|---|---|---|---|
| Marker | Physical Position* |
Location | Dominant P-value |
Dominant Admixture- Adjusted P-value |
Additive P-value |
Additive Admixture- Adjusted P-value |
Recessive P-value |
Recessive Admixture- Adjusted P-value |
| rs9479134 | 152281109 | Intron 2 | 0.006 | 0.021 | -- | -- | -- | -- |
| rs1709183 | 152286109 | Intron 2 | 0.071 | 0.072 | 0.035 | 0.036 | 0.108 | 0.113 |
| rs2175898 | 152289065 | Intron 2 | 0.029 | 0.028 | -- | -- | -- | -- |
| rs3020368 | 152463303 | Intron 5 | 0.018 | 0.017 | -- | -- | -- | -- |
| rs2982896 | 152491606 | Intron 6 | 0.031 | 0.032 | -- | -- | -- | -- |
| rs2813545 | 152524431 | 3′ UTR | 0.078 | 0.074 | 0.025 | 0.025 | 0.040 | 0.043 |
| rs2813562 | 152538434 | Exon 9 | 0.171 | 0.167 | 0.034 | 0.034 | 0.017 | 0.019 |
P-values <0.05 are shown in bold
*
NCBI Build 35 (May 2004).
P-values <0.05 are shown in bold
*
NCBI Build 35 (May 2004).