Table 1.
Quartiles of Soluble Endothelial Protein C Receptor (ng/ml)* |
|||||
---|---|---|---|---|---|
65.4–121.7 | 121.9–139.8 | 140.1–169.5 | 170.4–1381 | p for difference overall | |
No. of controls† | 259 | 259 | 260 | 260 | |
Age (years)† | 59.7 | 61.8 | 64.3 | 63.5 | <0.001 |
CHS (%)† | 24 | 35 | 46 | 43 | <0.001 |
White (%)† | 62 | 79 | 75 | 77 | <0.001 |
Men (%)† | 33 | 47 | 46 | 48 | <0.001 |
Body mass index | 27.2 | 27.6 | 27.7 | 27.4 | 0.71 |
Diabetes (%) | 11 | 8 | 13 | 14 | 0.15 |
Blood type non-O, % | 46 | 55 | 50 | 59 | 0.02 |
Factor VIII (%) | 124 | 126 | 131 | 131 | 0.16 |
Protein C (mg/L)‡ | 3.1 | 3.0 | 3.2 | 3.4 | <0.001 |
F5 AA/AG genotype (%) | 3 | 4 | 3 | 2 | 0.76 |
F2 AA/AG genotype (%) | 3 | 2 | 2 | 1 | 0.31 |
PROCR AG/GG genotype (%) | 0 | 1 | 1 | 66 | <0.001 |
Quartiles based on the distribution in combined Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health Study (CHS) controls.
Unadjusted
Protein C was available only for the ARIC subsample (n=642 for ARIC controls).