Table 2.

Odds ratios (OR) and 95% confidence intervals (CI) of venous thromboembolism (VTE) according to quartiles of soluble endothelial protein C receptor levels: LITE 1987–2002.

	Soluble Endothelial Protein C Receptor (ng/ml)*
	65.4–121.7	121.9–139.8	140.1–169.5	170.4–1381
Total (case n/control n)	112/259	118/259	95/260	133/260
Unadjusted OR (95% CI)	1.0	1.05 (0.77–1.44)	0.85 (0.61–1.17)	1.18 (0.87–1.60)
Age-, race-, and sex-adjusted OR (95% CI)	1.0	1.05 (0.77–1.44)	0.83 (0.60–1.15)	1.17 (0.86–1.59)
Multivariable adjusted OR† (95% CI)	1.0	1.06 (0.75–1.48)	0.88 (0.62–1.25)	1.07 (0.77–1.49)
ARIC (case n/control n)	77/196	65/168	51/140	79/148
Age-, race-, and sex-adjusted OR (95% CI)	1.0	0.99 (0.66–1.46)	0.93 (0.61–1.41)	1.36 (0.93–1.99)
CHS (case n/control n)	35/63	53/91	44/120	54/112
Age-, race-, and sex-adjusted OR (95% CI)	1.0	1.07 (0.62–1.83)	0.68 (0.39–1.17)	0.89 (0.52–1.51)
Non-white (case n/control n)	35/99	26/55	26/65	39/59
Age-, race-, and sex-adjusted OR (95% CI)	1.0	1.31 (0.71–2.41)	1.10 (0.61–2.01)	1.84 (1.05–3.22)
White (case n/control n)	77/160	92/204	69/195	94/201
Age-, race-, and sex-adjusted OR (95% CI)	1.0	0.93 (0.64–1.34)	0.72 (0.49–1.06)	0.96 (0.66–1.39)
Men (case n/control n)	46/85	58/123	42/120	55/125
Age-, race-, and sex-adjusted OR (95% CI)	1.0	0.88 (0.55–1.43)	0.64 (0.39–1.07)	0.81 (0.50–1.31)
Women (case n/control n)	66/174	60/136	53/140	78/135
Age-, race-, and sex-adjusted OR (95% CI)	1.0	1.16 (0.76–1.76)	0.99 (0.64–1.52)	1.51 (1.01–2.26)
Idiopathic VTE (case n/control n)	50/259	53/259	38/260	53/260
Age-, race-, and sex-adjusted OR (95% CI)	1.0	1.08 (0.70–1.66)	0.75 (0.47–1.20)	1.07 (0.69–1.64)
Secondary VTE (case n/control n)	62/259	65/259	57/260	80/260
Age-, race-, and sex-adjusted OR (95% CI)	1.0	1.03 (0.70–1.53)	0.89 (0.59–1.34)	1.26 (0.86–1.83)

^*Quartiles based on the distribution in combined Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health Study (CHS) controls.

^†Adjusted for age, race, sex, body mass index, diabetes and ABO blood type.