. Author manuscript; available in PMC: 2009 Sep 28.

Published in final edited form as: Cancer Chemother Pharmacol. 2008 May 29;63(4):615–625. doi: 10.1007/s00280-008-0774-y

Table 1.

Pharmacokinetics parameters resulting from fitting of a two-compartment, open, linear model to plasma 10058-F4 concentration-versus-time data

Parameters	Mice bearing DU145 tumor (Mean ± SD)	Mice bearing PC-3 tumor (Mean ± SD)
Ke (h⁻¹)	3.817 ± 0.229	3.825 ± 0.185
Kcp (h⁻¹)	0.2459 ± 0.066	0.06958 ± 0.0145
Kpc (h⁻¹)	1.044 ± 0.157	0.6191 ± 0.095
CLt (ml/h kg⁻¹)	610.6 ± 39.89	808.0 ± 42.347
Vc (ml/kg)	160.0 ± 17.54	211.3 ± 18.079
α (h⁻¹)	4.146 ± 0.292	3.907 ± 0.197
β (h⁻¹)	0.9617 ± 0.123	0.6060 ± 0.091
t1/2-α (h)	0.1672 ± 0.012	0.1774 ± 0.089
t1/2-β (h)	0.7208 ± 0.096	1.144 ± 0.122

Vc volume of the central compartment, Ke elimination constant, Kcp transfer constant from the central to the peripheral compartment, Kpc from the peripheral compartment to the central compartment, t1/2 terminal half-life, CLt total body clearance; α and β are the macroscopic rate constants for distribution and elimination, respectively