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Inhibition of PKC prevents up-regulation of PAI-1 expression by EGF. A172 cells were pretreated with 10 µM LY294002, 1 µM U0126, 10 µM SB202190, 1 µM SP600125, 100 nM staurosporin, 5 µM BAY11–7082 (A), the indicated combination of the inhibitors (B), the indicated concentration of staurosporin (C), or 5 µM Gö6983 (D) for 1 h and subsequently stimulated with EGF for 7 h. RNA was isolated, and PAI-1 expression was analyzed by Northern blotting.
