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. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: Neurotoxicology. 2008 Aug 9;29(5):846–854. doi: 10.1016/j.neuro.2008.07.008

Figure 5.

Figure 5

Time-course distribution of B(a)P metabolites representative of toxification (BaP 7,8-diol) and detoxification (3-OH B(a)P) processes in A) brain tissues and B) plasma. Timed-pregnant dams received 300 μg B(a)P/kg BW via gavage on GD14-17. Offspring pups were sacrificed on PND 0, 3, 5, 10, 15, and 20 and metabolite levels were determined as outlined in the methods and materials section. Values represent mean + S.E.M. Owing to the limited volume of blood that could be obtained at PND0 & PND5, whole blood was used in lieu of plasma, whereas plasma was used for the remaining time points for metabolite analysis. Values are mean ± SEM with *p<0.05 for n=3 litters for control and n=3 litters for B(a)P-exposed cerebrocortical brain tissue for metabolite concentrations in brain tissues as compared to plasma. The asterisks denote statistical significance.