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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Jul 18;19(17):4967–4970. doi: 10.1016/j.bmcl.2009.07.072

Scheme 1.

Scheme 1

Library synthesis of 4a–n. Reagents and conditions: (a) RR'NH, THF, 55 °C, (24-80%). All library compounds were purified by mass-directed prep LC where required.17,18