Table 3.
SAR evaluation of carboxylic acid mimetics, 7a-c.
| Compound | EC50 (μM) mGluR44,a |
% Glu Max |
|---|---|---|
| 7a | 2.0 | 55 |
| 7b | >10 | 152 |
| 7c | Inactive |
a
Represents the average of at least one experiment performed in triplicate.
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