Table 1.

Longitudinal multiple logistic regression models for microvascular complications

	Intensive		Conventional		Combined
	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P
Retinopathy
Model 1
A1C eligibility, DCCT	0.94 (0.76–1.16)	0.59	1.04 (0.90–1.21)	0.52	1.02 (0.90–1.15)	0.73
Mean BG, DCCT	1.31 (0.96–1.77)	0.08	1.32 (1.19–1.46)	<0.001	1.31 (1.19–10.44)	<0.001
MAGE, DCCT	1.03 (0.82–1.29)	0.27	0.92 (0.83–1.02)	0.15	0.96 (0.88–1.05)	0.45
Mean A1C, EDIC	1.66 (1.31–2.150)	<0.001	1.29 (1.08–1.54)	0.004	1.41 (1.22–1.62)	<0.001
Model 2
A1C eligibility, DCCT	0.94 (0.76–1.16)	0.59	1.04 (0.90–1.201)	0.5	1.02 (0.90–1.15)	0.11
Mean BG, DCCT	1.26 (0.90–1.76)	0.16	1.35 (1.21–1.49)	<0.001	1.33 (1.21–1.51)	<0.001
SDBG, DCCT	1.16 (0.69–1.93)	0.55	0.82 (0.65–1.03)	0.09	0.9 (0.74–1.10)	0.32
Mean A1C, EDIC	1.66 (1.31–2.11)	<0.001	1.26 (1.06–1.51)	0.008	1.39 (1.20–1.60)	<0.001
Nephropathy
Model 1
A1C eligibility, DCCT	1.31 (0.97–1.76)	0.07	1.35 (1.07–1.71)	0.011	1.33 (1.09–1.610)	0.003
Mean BG, DCCT	0.97 (0.62–1.52)	0.9	1.08 (0.93–1.26)	0.29	1.08 (0.93–1.24)	0.29
MAGE, DCCT	1.13 (0.90–1.43)	0.26	0.99 (0.86–1.15)	0.96	1.01 (0.89–1.14)	0.8
Mean A1C, EDIC	1.46 (1.11–1.91)	0.005	1.34 (1.02–1.76)	0.03	1.38 (1.13–1.67)	0.001
Model 2
A1C eligibility, DCCT	1.29 (0.96–1.73)	0.08	1.36 (1.07–1.71)	0.01	1.32 (1.09–1.60)	0.003
Mean BG, DCCT	1.08 (0.65–1.78)	0.75	1.1 (0.95–1.28)	0.17	1.11 (0.96–1.28)	0.14
SDBG, DCCT	0.99 (0.54–1.83)	0.99	0.83 (0.59–1.18)	0.31	0.86 (0.64–1.15)	0.31
Mean A1C, EDIC	1.44 (1.11–1.86)	0.005	1.33 (1.01–1.76)	0.037	1.38 (1.13–1.67)	0.001

Models adjusted for age (EDIC baseline), disease duration (EDIC baseline), and sex. Retinopathy models further adjusted for laser therapy in DCCT, and nephropathy further adjusted for patients with microalbuminuria at the DCCT closeout. Example interpretation: A1C odds ratio represents proportionate change per 1% unit difference in A1C. BG, blood glucose; SDBG, SD of blood glucose.