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Solution structure of the human TRIM5 B-box 2 domain. (A) Superposition of 20 NMR structures showing the α-helix in red, the β-strands in blue, and the Zn2+ in green. (B) Ribbon diagram of the NMR structure shown in panel A from the same perspective. The Zn2+ coordinating residues (CHCDC2H2) are also shown in green. (C) Electrostatic mapping of the B-box 2 surface, highlighting the positions of the positive (blue), negative (red), or neutral (white) charges.
