FIG. 7.
Binding of additional TRIM5αrh mutants to assembled HIV-1 capsid complexes. (A) The binding of the indicated TRIM5αrh variants to HIV-1 CA-NC complexes assembled in vitro were assessed as described in the Fig. 6 legend and Materials and Methods. (B) The relative capsid-binding ability and HIV-1-restricting activity of each TRIM5αrh B-box 2 variant were assessed as described in the Table 2 footnotes and in Materials and Methods. The means for the relative capsid-binding abilities associated with each HIV-1 restriction group are indicated by horizontal bars. The Spearman rank correlation coefficient, rs, is 0.8421, with a 95% confidence interval of 0.779 to 0.905 (two-sided P value of <0.001).