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Model for the role of the TRIM5α B-box 2 domain in HIV-1 restriction. The TRIM5αrh dimer is depicted, with the B-box 2 domains (magenta) and B30.2(SPRY) domains (blue) highlighted. Interactions involving the cluster 1 region of the B-box 2 domain increase the avidity of TRIM5αrh for the retroviral capsid, promoting the aggregation of the TRIM5αrh protein on the capsid surface.
