TABLE 2.
t statistic for the total fluxes in surviving (n = 147) versus nonsurviving (n = 53) animalsa
| Location |
t statistic on day postinfection:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 9 | 10 | |
| Nasal cavity | 5.94d | 6.89d | 7.33d | 8.61d | 8.64d | 3.28b | 8.04d | 2.73b | 0.82 |
| Lungs | 3.87c | 3.26b | 4.31c | 5.72d | 6.35d | 3.09b | 7.31d | 2.27 | 0.73 |
| Liver | 3.21b | 4.94c | 7.45d | 6.27d | 5.27d | 3.49b | 6.33d | 2.13 | 2.78b |
| Spleen | 7.09d | 7.72d | 11.04d | 9.57d | 8.18d | 2.88b | 7.20d | 6.33d | 1.58 |
Two hundred BALB/c mice in six experiments were challenged with WRvFire alone (105 PFU) or received intraperitoneal injections with VIGIV at the concentrations indicated in Fig. 4 2 days prior to challenge. The animals were imaged within their survival period or until day 10 postinfection. t tests were performed for fluxes in internal organs between surviving and nonsurviving mice irrespective of treatment. n = 200.
P <0.05.
P <0.0005.
P <0.000005.