TABLE 3.

ROC analysis of bioluminescence in the internal organs of WRvFire-infected mice recorded on days 1 to 5 postinfection

Area	Day	AUCa	95% CIb for AUC	Sensitivity (%)c	Specificity (%)c
Nasal cavity	1	0.78	(0.69, 0.84)	68	81
	2	0.78	(0.70, 0.85)	68	77
	3	0.78	(0.71, 0.84)	79	68
	4	0.83	(0.76, 0.89)	89	67
	5d	0.85	(0.79, 0.90)	87	74
Lungs	1	0.75	(0.68, 0.83)	87	64
	2	0.72	(0.64, 0.79)	96	46
	3	0.76	(0.69, 0.83)	94	54
	4	0.78	(0.71, 0.84)	92	62
	5	0.83	(0.77, 0.88)	91	67
Liver	1	0.66	(0.57, 0.75)	57	73
	2	0.75	(0.68, 0.82)	83	61
	3	0.88	(0.83, 0.92)	85	80
	4	0.89	(0.84, 0.93)	96	69
	5	0.91	(0.86, 0.94)	100	72
Spleen	1	0.80	(0.71, 0.86)	60	89
	2	0.83	(0.77, 0.89)	81	76
	3	0.91	(0.86, 0.94)	94	73
	4	0.89	(0.84, 0.93)	96	73
	5	0.87	(0.82, 0.92)	89	73

^aAUCs were calculated using total fluxes recorded for the surviving and nonsurviving animals described in the legend to Fig. 6.

^bCI, confidence interval.

^cSensitivity and specificity parameters were obtained from generated ROC curves and are shown for maximized combined sensitivity and specificity. n = 200.

^dData for the days when the combined sensitivity and specificity reached maximum for each organ are in bold type.