TABLE 1.

Plasma TFV and FTC levels

Study group (regimen) and animal identifier	Animal wta (kg)	Animal ageb (mo)	No. of measurements below LOQc (%)	Mean plasma drug concn, ng/ml (95% confidence limit)	% Drug applied detected in plasma at 30 mind (95% confidence limit)
TFV (TFV only)
PRa2	6.36	65	6 (30)	22.4 (13.8-31.0)	0.016 (0.010-0.022)
PVb2	6.96	61	9 (45)	15.4 (10.0-20.9)	0.012 (0.008-0.016)
PHb2	8.22	63	13 (65)	13.6 (6.0-21.2)	0.012 (0.005-0.019)
PEc2	6.54	60	10 (50)	21.2 (9.7-32.7)	0.015 (0.007-0.024)
PUc2	6.76	56	11 (55)	15.3 (6.7-23.9)	0.011 (0.005-0.018)
PYh1	11.62	146	9 (45)	11.2 (8.9-13.5)	0.014 (0.011-0.017)
Total	7.74	75	58 (48)	16.4 (13.1-19.7)	0.014 (0.011-0.017)
TFV (TFV-FTC)
PRa2	6.36	65	4 (20)	34.7 (16.6-52.7)	0.024 (0.012-0.037)
PVb2	6.96	61	2 (10)	52.0 (17.6-86.4)	0.040 (0.013-0.066)
PHb2	8.22	63	3 (15)	25.3 (19.6-30.9)	0.023 (0.018-0.028)
PCt1	8.00	95	4 (20)	38.1 (17.4-58.8)	0.034 (0.015-0.052)
PSc2	6.54	58	2 (10)	49.2 (25.8-72.7)	0.035 (0.019-0.052)
PDe2	5.86	50	6 (30)	33.1 (14.0-52.2)	0.021 (0.009-0.034)
Total	6.99	65	21 (18)	38.7 (29.6-47.8)	0.030 (0.023-0.037)
FTC (TFV-FTC)
PRa2	6.36	65	0 (0)	133.6 (45.6-221.6)	0.019 (0.006-0.031)
PVb2	6.96	61	2 (10)	155.9 (41.2-270.7)	0.024 (0.006-0.041)
PHb2	8.22	63	0 (0)	124.6 (76.2-173.0)	0.023 (0.014-0.031)
PCt1	8.00	95	4 (20)	187.4 (43.2-331.6)	0.033 (0.008-0.058)
PSc2	6.54	58	0 (0)	228.3 (103.6-352.9)	0.033 (0.015-0.051)
PDe2	5.86	50	0 (0)	131.4 (36.7-226.2)	0.017 (0.005-0.029)
Total	6.99	65	6 (5)	160.2 (116.1-204.3)	0.025 (0.018-0.031)

^aBaseline weight measured prior to first SHIV challenge.

^bAge of macaque at start of study.

^cThe LOQ for both TFV and FTC was 10 ng/ml.

^dCalculated by dividing the weight-adjusted plasma drug concentration (estimated assuming a plasma volume of 33 ml/kg) (8) by the amount of drug applied (0.03 g TFV; 0.15 g FTC).