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. Author manuscript; available in PMC: 2010 Aug 13.
Published in final edited form as: J Phys Chem B. 2009 Aug 13;113(32):11179–11185. doi: 10.1021/jp9033936

Figure 7.

Figure 7

Detailed proposed model of PAMAM dendrimer causing hole formation analogous to schematic models (ii) and (iii). (A) Simulated density map of the lipophilic part of the bilayer. (B) Simulated density map of the hydrophilic (headgroup) part of the bilayer. X-axis is normal to the bilayer plane. (C) Sketch demonstrating the formation of a nanoparticle-bilayer complex and corresponding breakage of the original membrane. (D) AFM pictures of lipid bilayers with holes made by charged PAMAM dendrimers. Particle radius Rp = 2.4 nm. Reprinted with permission from reference 10.