Table 1. Association between the p53 Arg72Pro polymorphism and childhood tanning tendency according to hair color among controls.
| Black/dark brown hair | |||
|---|---|---|---|
| Tan (%) | Non-tan (%) | OR (95% CI) | |
| Arg/Arg | 774 (56) | 53 (67) | 1.00 |
| Arg/Pro | 511 (37) | 22 (28) | 1.59 (0.96-2.65) |
| Pro/Pro | 91 (7) | 4 (5) | 1.56 (0.55-4.40) |
| P, trend | 0.08 | ||
| Light brown hair | |||
| Tan (%) | Non-tan (%) | OR (95% CI) | |
| Arg/Arg | 668 (54) | 53 (54) | 1.00 |
| Arg/Pro | 480 (39) | 40 (41) | 0.95 (0.62-1.46) |
| Pro/Pro | 85 (7) | 5 (5) | 1.35 (0.52-3.47) |
| P, trend | 0.79 | ||
| Red/blonde hair | |||
| Tan (%) | Non-tan (%) | OR (95% CI) | |
| Arg/Arg | 231 (59) | 64 (63) | 1.00 |
| Arg/Pro | 142 (36) | 34 (33) | 1.16 (0.73-1.84) |
| Pro/Pro | 17 (4) | 4 (4) | 1.18 (0.38-3.62) |
| P, trend | 0.54 | ||
Crude ORs of childhood tanning tendency according to the p53 genotypes were calculated among the 1,455 black/dark brown hair women, among the 1,331 light brown hair women, and among the 492 red/blonde hair women (the controls in four nested studies of skin cancer, colon cancer, colon polyps, and breast cancer within the NHS). OR>1 means increased likelihood of tanning. Four categories of the responses to the question of childhood tanning tendency were grouped into tan (light tan or average tan or tan) and non-tan (practically none). The percentages may not sum to 100 due to rounding.