Table 2. Interaction between the p53 Arg72Pro polymorphism and MC1R variants on childhood tanning tendency among controls.
| p53\MC1R | WT/WT | WT/NRHC or NRHC/NRHC | WT/RHC | RHC/RHC or NRHC/RHC |
|---|---|---|---|---|
| Arg/Arg | ||||
| Tan/Non-tana | 124/7 | 173/20 | 65/12 | 35/15 |
| Crude OR | 1.00 | 0.49 (0.20-1.19) | 0.31 (0.12-0.81) | 0.13 (0.05-0.35) |
| Multivariate ORb | 1.00 | 0.45 (0.18-1.15) | 0.36 (0.13-1.01) | 0.26 (0.09-0.73) |
| Arg/Pro or Pro/Pro | ||||
| Tan/Non-tana | 101/6 | 105/13 | 54/10 | 21/16 |
| Crude OR | 0.95 (0.31-2.92) | 0.46 (0.18-1.19) | 0.31 (0.11-0.84) | 0.07 (0.03-0.20) |
| Multivariate ORb | 0.68 (0.21-2.19) | 0.45 (0.17-1.24) | 0.28 (0.09-0.85) | 0.14 (0.05-0.41) |
WT stands for consensus allele. NRHC stands for non-red hair color allele. RHC stands for red hair color allele.
Four categories of the responses to the question of childhood tanning tendency were grouped into tan (light tan or average tan or tan) and non-tan (practically none).
a
The number of participants does not add up to the total women because of missing genotypes.
b
Unconditional logistic regression adjusted for natural skin color and natural hair color (p, interaction, 0.55).