Table 5. Melanoma risk by p53 Arg72Pro polymorphism and constitutional susceptibility score.
Constitutional susceptibility score | Arg/Arg | Arg/Pro | Pro/Pro | P, trend |
---|---|---|---|---|
Low | ||||
Case/Controlsa | 18/150 | 12/108 | 2/17 | |
Multivariate ORb | 1.00 | 0.95 (0.44-2.05) | 1.03 (0.22-4.91) | 0.99 |
Medium | ||||
Case/Controlsa | 30/171 | 19/97 | 3/17 | |
Multivariate ORb | 1.48 (0.79-2.77) | 1.69 (0.84-3.39) | 1.51 (0.40-5.70) | 0.70 |
High | ||||
Case/Controlsa | 61/173 | 56/104 | 10/13 | 0.01 |
Multivariate ORb | 3.00 (1.69-5.33) | 4.62 (2.55-8.37) | 7.09 (2.70-18.66) |
p-value for trend was calculated across the three p53 genotypes.
The number of participants does not add up to the total women because of missing genotypes.
Unconditional logistic regression adjusted for the matching variables: age and race (Caucasian/missing) (p, interaction, 0.15).