Table 5. Melanoma risk by p53 Arg72Pro polymorphism and constitutional susceptibility score.
| Constitutional susceptibility score | Arg/Arg | Arg/Pro | Pro/Pro | P, trend |
|---|---|---|---|---|
| Low | ||||
| Case/Controlsa | 18/150 | 12/108 | 2/17 | |
| Multivariate ORb | 1.00 | 0.95 (0.44-2.05) | 1.03 (0.22-4.91) | 0.99 |
| Medium | ||||
| Case/Controlsa | 30/171 | 19/97 | 3/17 | |
| Multivariate ORb | 1.48 (0.79-2.77) | 1.69 (0.84-3.39) | 1.51 (0.40-5.70) | 0.70 |
| High | ||||
| Case/Controlsa | 61/173 | 56/104 | 10/13 | 0.01 |
| Multivariate ORb | 3.00 (1.69-5.33) | 4.62 (2.55-8.37) | 7.09 (2.70-18.66) |
p-value for trend was calculated across the three p53 genotypes.
a
The number of participants does not add up to the total women because of missing genotypes.
b
Unconditional logistic regression adjusted for the matching variables: age and race (Caucasian/missing) (p, interaction, 0.15).