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. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: J Mol Biol. 2005 Sep 9;352(1):1–10. doi: 10.1016/j.jmb.2005.06.072

Table 3.

Binding sites for PLCγ1-SH3 in selected signaling partners

Group Sequence Positions Protein Reference
A PPVPPQRPa 186−193 SLP-76 This work
XPXXPXRP IPLPPPRP 158−165 MIST 17
PPPPPDRP 544−551 c-Cbl 36
PPPVPLRP 1216−1223 SOS1 18
PPGLPPRPa 528−535 TNK1 37
APPVPSRP 812−819 Dynamin 20
PPQVPSRPa 829−836 Dynamin 20
B LPPVPPRL 493−500 c-Cbl 36
XPXXPXRX PPPPPPRD 1203−1210 SOS1 18
PPPLPPRK 1146−1153 SOS1 18
PPAIPPRQ 1172−1179 SOS1 18
APPVPPRQ 1288−1295 SOS1 18
C GPVGPELP 326−333 CAIR-1/BAG-3 19
XPXXPXXP VPCPPPSP 371−378 CAIR-1/BAG-3 19
APPPPPVP 294−301 SAM 68 38

Sequences of proteins known to bind PLCγ1-SH3 were compared to the SLP-76 186−193 sequence to identify potential binding sites. Consensus motifs for each group are indicated. Possible critical residues are in bold.

a

Direct interaction of peptides bearing this sequence with PLCγ1-SH3 has been reported.