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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Neurochem. 2009 Jul 17;110(6):1876–1884. doi: 10.1111/j.1471-4159.2009.06291.x

Fig. 2.

Fig. 2

Neurite outgrowth induced by NGF ± compounds from screening. LSU-31 (Hoechst 33258), LSU-40 (Netropsin), LSU-42 (Distamycin A), and LSU-44 (DAPI) were discovered during our initial screening and tested for their effects on neurite outgrowth in comparison to olanzapine. The compounds were tested at 10 μM, 40 μM, 20 μM, and 5 μM, respectively. (a) Photographs show changes in cellular morphology and neurite extension enhanced by the combination of NGF (20 ng/ml, ~ 0.8 nM) and compounds. (b) Quantification of the effects of NGF and NGF + compounds on neurite length and number of responding cells. Results are shown as average neurite length or cell number ± the standard error (S.E.). Significant differences from NGF alone, as determined by Student's t-test, are indicated with asterisks (*p<0.05). Actual P values for significant effects (*) are listed in parentheses as follows: for neurite length, LSU-31 (< 0.001), LSU-42 (< 0.001), LSU-44 (0.004); and for cell number, LSU-44 (0.006).