Table 4.

Data Analysis of Subjective Memory Complaints and Objective Neuropsychological Testing using Pearson^*

	Cross-sectional Data^a		Change Data^b

Cognitive Domains and Neuropsychological Test Components	Correlation between Likert score and 6 year cognitive score (95%CI)	Sample Partial Correlation between Likert score and 6 year score given CESD (95%CI)	Correlation between Lund score and change in actual cognitive scores from baseline to 6 years (95% CI)
Verbal Memory
RAVLT - total score	.24 (.09, .38)	.28 (.14, .41)	.18 (.04, .33)
RAVLT – delayed recall	.17 (.02, .31)		.20 (.05, .34)
RAVLT – retention			.16 (.01, .30)
RAVLT – recognition
Visual Memory
RCF – retention	.18 (.03, .32)
RCF – delayed recall	.17 (.02, .32)
Visuoconstruction
RCF – copy		.16 (.01, .30)
Block design
Language
Boston Naming	.17 (.02, .31)	.26 (.11, .39)
Motor Speed
Pegboard – dominant		.23 (.09, .37)
Pegboard – non-dom
Psychomotor Speed
Trail Making – Part A			.20 (.05, .34)
Written Alphabet			.18 (.03, .32)
Attention
RAVLT – Trial 1	.15 (.00, .29)	.17 (.02, .31)
Mini-mental – attention
Executive Function
Trail Making – Part B
Working Memory
Letter-Number	.18 (.03, .32)		n/a
sequencing task

Cognitive test scores adjusted for age, gender, education;

for this cross-sectional analysis, we asked: Are there correlations between the Likert memory scale score, which asks patients to rank their memory at their 6 year visit, and their 6 year cognitive test scores? For the Likert memory scale score – subjects were asked to rank their memory on a scale of 1-10 (with 10 being the best memory score) at their 6 year visit.

For this change analysis, we asked: Are there correlations between the Lund memory questionnaire score, which asks patients to compare their memory at 6 years to before the study started and the change in their cognitive test scores from baseline to 6 years? Lund memory score is a composite of 7-items (from the Lund questionnaire)(6). Patients were asked if each of the memory items had become better (score of +1), worse (score of -1), or remained the same (score of 0) when comparing their memory today to 6 years ago, before the study started. CES-D is the depression index score (8).