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. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: Curr Opin Pharmacol. 2007 Nov 19;7(6):557–562. doi: 10.1016/j.coph.2007.10.002

Figure 1.

Figure 1

A scheme showing that tastant-induced signaling via T2Rs and T1Rs in the apical portion of an open enteroendocrine cell engages gustducin, PLCβ2, TRPM5 and L-type VSCCs leading to an elevation of the intracellular concentration of Ca2+. This second messenger in combination with diacylglycerol (DAG)-mediated activation of protein kinase C (PKC) and protein kinase D (PKD) triggers the release of GI peptides into the basolateral portion of the cell. The gut hormones, acting in an endocrine and/or paracrine manner, exert multiple physiological effects. Detailed description and abbreviations can be found in the text.