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The H258N transgene completely rescues photoreceptors in Pde6brd1/Pde6brd1 mice. Light micrographs of retina from a 6-month-old H258N mouse (A) and a 3-month-old homozygote Pde6brd1/Pde6brd1 (B) in DBA background. OS, outer segments; ONL, outer nuclear layer; INL, inner nuclear layer; GC, ganglion cell layer. OS and ONL comprise the photoreceptor layer. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.)
