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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2009 May;68(5):515–524. doi: 10.1097/NEN.0b013e3181a24b53

Figure 5.

Figure 5

Graphs of nigral tyrosine hydroxylase (TH) cell loss, striatal TH terminal density, and dopamine content. (A) Stereological estimates of TH cell loss in the SN at 6 weeks are expressed relative to empty vector control. Expression of both wild type (wt) and S129 mutant 〈-synuclein resulted in significant TH cell loss (mean 25.8%) compared to control (*p < 0.05, **p < 0.01, ***p < 0.001; F[3,24] = 9.96, p = 0.0002). However, TH cells did not differ among wt and S129A and S129D groups. (B) Optical density scan array analysis of striatal TH terminal density showed a 16% to 25% decrease for wt and S129 mutants, but no significant difference among groups (F[3,27] = 2.514, p = 0.080). (C) Relative striatal dopamine (DA) (compared to contralateral striatum injected with empty vector control) but not 3,4-dihydroxyphenlyacetic acid (DOPAC) content was reduced only in S129 mutants.