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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Hum Pathol. 2008 Oct 29;40(3):341–348. doi: 10.1016/j.humpath.2008.08.006

TABLE 2.

Pathologic and Molecular Data

Case Tissue
Analyzed
Initial DDx Pattern Immunohistochemical Findings Karyotype FISH RT-PCR
CD56 Synaptophysin FOXO1 locus
rearrangement
1 P High grade neuroendocrine tumor Solid + 82–104, XXXX, t(2;13) (q35;q14)x2,+der(2) t(2;13)(q35;q14),+3,+7 +7,+12,+12,+4–9mar + PAX3-FOXO1
2 P Small cell carcinoma, esthesioneuroblastoma Solid + + NP NP PAX7-FOXO1
3 P High grade neuroendocrine tumor Solid + NP NP PAX3-FOXO1
4 P Lymphoma Solid + NP NP PAX3-FOXO1
5 M Acute hematologic malignancy NA NP NP 80–92, XXXX, i(1)(q10), t(2;13)(q35;q14)x2, inc +* NP
6 P Undifferentiated small round cell tumor Solid + 45, XX, −5, −13,+der(16) t(1;16)(q21;q13) + NP
7 P, M Small cell carcinoma, lymphoma, epithelial neoplasm, rhabdomyosarcoma NA NP t(2;13)(q35;q14) + NP

DDx, differential diagnosis; NP, not performed; M, metastasis; NA, not available.

*

Metaphase FISH with paint probes confirmed the presence of a t(2;13) in this case.

Conventional cytogenetic studies were performed on the primary tumor of this case and FISH studies on a neck metastasis 5 years later.