. Author manuscript; available in PMC: 2009 Sep 28.

Published in final edited form as: J Infect Dis. 2008 Aug 1;198(3):418–426. doi: 10.1086/588826

Table IV. Logistic regression analysis confirming the strong association between PPF and IL-10 levels.

Stepwise regression analysis was performed as described in the methods. Praziquantel classes were defined as indicated in the legend to table II; cytokine levels were assigned to three classes of equal size. We compared the (CLM, CLH, D, E, F) PPF subjects or the (CLH, D, E, F) PPF subjects with the group of patients with no or mild fibrosis (A,B,C,CLL PPF subjects).

Phenotype	Covariates	Odds Ratio	CI	p
No or Mild PPF / Advanced or severe PPF (A, B, C, CLL ) / (CLM ,CLH, D, E,F)	IL-10 >50 / <50 pg/ml	4	1.4-11	1.6 × 10^-3
	Praziquantel T >10T / <10T	3.9	1.7-9	8 × 10^-3
No or Mild PPF / Severe PPF (A, B, C, CLL ) / (CLH, D, E, F)	IL-10 >50 / <50 pg/ml	10.8	3.2-38	1 × 10^-4^*
	Years of fishing	1.05	1.003-1.1	0.03
	Praziquantel T >10T / <10T	7.3	1.7-33	8 × 10^-3

When “treatments” was excluded from the analysis, low IL-10 levels remained associated with phenotype (p=6 × 10^-4, OR=6 and CI=2.1-16.6)