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. Author manuscript; available in PMC: 2009 Sep 28.
Published in final edited form as: Nature. 2008 Dec 10;458(7235):206–210. doi: 10.1038/nature07662

Figure 3. In vivo PD-1 blockade during chronic SIV infection enhances SIV-specific humoral immunity.

Figure 3

a) Expression of PD-1 on memory (CD20+CD27+CD21-) and naïve (CD20+CD27-CD21+) B cells in blood following SIV infection and prior to in vivo PD-1 blockade. b) Titers of anti-SIV Env binding Ab in serum following blockade. c) Ki-67 expression (marker for proliferation) on memory and naïve B cells following blockade. Numbers on the FACS plots represent Ki-67 positive cells as a percent of respective total cells. Macaques RAf11 and RJd11 were treated simultaneously with anti-PD-1 Ab and anti-retroviral therapy at 22 weeks post SIV infection.