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Polζ deficiency (rev3) renders yeast resistant to Cr(VI) forward, but not frameshift, mutagenesis. Yeast (SJR751) were exposed to the indicated amounts of Cr(VI) and processed for (A) CAN1 mutagenesis and (B) frameshift mutagenesis as described in Methods. * = significantly (P<0.05)) different from respective untreated control; # = significantly different from Wt cells. The data are presented as the mean ± SE of at least 3 independent experiments.
