Figure 1.
X-ray structures of trisoxazoles bound to G-actin (data adapted from Rayment et al. Ref vi. (a) jaspisamide A (6): torsional angles C8(Me)-C8-C9-C10 = −57.4°, H8-C8-C9-H9 =+67.9° (b) kabiramide C (1): torsional angles C8(Me)-C8-C9-C10 = −67.3°, H8-C8-C9-H9 =+75.8° Side chains of each compound (upper left) and protein residues have been removed for clarity