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Effect of intraperitoneal and intra-cerebroventricular CrPic injection on 24-h food intake in Sprague-Dawley rats. (A) 24-h fasted rats were injected intraperitoneally with increasing doses of CrPic, and 24-h food intake was assessed. (B) Rats implanted with an indwelling intracerebroventricular cannula were injected intracerebroventricularly with lower doses of CrPic, and 24-h food intake was assessed. *P < 0.05, **P < 0.01 versus vehicle (Veh).
