Table 3. Normal Eye Range and Treatment Eye Differences for Three Previously Reported Cynomolgus EEG monkeys11-13 Compared the PID (PIPD) Maximum.
| Optic Disk Size | Normal Eye Range of EEG Monkeys | EEG Monkey 1 ΔEEG (ΔEEG/N%)1 |
EEG Monkey 2 ΔEEG (ΔEEG/N%) |
EEG Monkey 3 ΔEEG (ΔEEG/N%) |
PID (PlPD%) Maximum2 |
|---|---|---|---|---|---|
| Vertical Length3 (μm) | 1337 – 1459 | 108 (8.1) | 1 (0.1) | 3 (0.2) | 40 (2.8) |
| Horizontal Length3 (μm) | 1017 – 1055 | 47 (4.6) | 2 (0.2) | 68 (6.5) | 25 (2.6) |
| Disk Area3 (mm2) | 1.068 – 1.209 | 0.140 (13.1) | 0.001 (0.1) | 0.081 (6.7) | 0.036 (3) |
| Neural Canal Architecture | |||||
| BMO Offset (μm) | 579 – 615 | 39* (6.7) | 2 (0.3) | 21 (3.4) | 9 (1.5) |
| ASCO Offset (μm) | 648 – 724 | 71* (9.8) | 11 (1.7) | 1 (0.1) | 16 (2.1) |
| ALI Offset (μm) | 649 – 736 | 70* (9.6) | 11 (1.7) | 4 (0.5) | 16 (2.2) |
| PLI Offset (μm) | 721 – 904 | 99* (11.0) | 39* (5.4) | 54* (6.5) | 18 (2.1) |
| PSCO Offset (μm) | 743 – 940 | 85* (9.0) | 19* (2.6) | 30* (3.5) | 22 (2.7) |
| ASAS Offset (μm) | 831 – 1038 | 98* (9.4) | 39* (4.7) | 74* (7.5) | 18 (2.1) |
| ASCO Depth (μm) | 22 – 53 | 7 (31.8) | 4 (13.8) | 2 (3.8) | 15 (100.9) |
| ALI Depth (μm) | 22 – 64 | 7 (31.8) | 18* (47.4) | 14* (21.9) | 20 (89.6) |
| PLI Depth (μm) | 86 – 166 | -5 (5.8) | 39* (23.5) | 14* (9.7) | 20 (16.8) |
| PSCO Depth (μm) | 104 – 181 | -9 (8.7) | 25* (13.8) | 7 (4.6) | 27 (17.1) |
| ASAS Depth (μm) | 125 – 185 | -25* (20.0) | 9 (4.9) | -36* (24.7) | 25 (19.4) |
| ONH Connective Tissue | |||||
| Lamina Cribrosa Position (μm) | -111 – -105 | -118* (115.7) | -97* (87.4) | -79* (75.2) | 16 (21.1) |
| Lamina Cribrosa Thickness (μm) | 83 – 128 | 61* (59.2) | 23* (18.0) | 26* (31.3) | 16 (18.0) |
| Sclera Flange Thickness (μm) | 60 – 76 | 7 (10.1) | 1 (1.3) | 8 (13.3) | 5 (8.8) |
| Mid-Peripapillary Sclera Position (μm) | -14 – 45 | 21* (46.7) | 3 (21.4) | 35* (94.6) | 18 (180) |
| Mid-Peripapillary Sclera Thickness (μm) | 113 – 136 | -4 (2.94) | -32* (25.4) | 1 (0.9) | 14 (9.2) |
| ONH Prelaminar Neural Tissue and Cupping | |||||
| Prelaminar Tissue Thickness (μm) | 95 – 110 | 82* (74.5) | 47* (47) | 58* (61.1) | 15 (8.9) |
| Post-BMO Cup Volume3 (mm3) | 0.010 – 0.054 | 0.127 (235.2) | 0.058 (446.2) | 0.090 (900) | 0.0056 (174.4) |
| Post-BMO Total Prelaminar Volume3 (mm3) | 0.159 – 0.231 | 0.308 (133.3) | 0.122 (76.7) | 0.191 (119.4) | 0.0440 (28.4) |
| Prelaminar Tissue Volume3 (mm3) | 0.232 – 0.289 | 0.167 (62.3) | 0.025 (10.8) | 0.002 (0.692) | 0.0334 (18.1) |
The treatment difference (ΔEEG) using overall EEG eye data minus normal eye data for three EEG monkeys and also expressed as percent treatment difference (difference magnitude divided by the normal eye measurement magnitude). Neural canal architures, ONH connective tissue and prelaminar neural tissue and cupping parameters data od the 3 EEG monkeys were adapted from previous reports11-13
PID/PIPD maximum is the upper limit of the PID/PIPD range reported in table 2 for each parameter
ANOVA (analysis of variance) were not applicable to these measurements in the 3 EEG monkeys
EEG eye value was significant different (P< 0.05 ANOVA) from the contralateral normal eye
Dark grey signifies both treatment difference magnitude and percent treatment difference exceeded the PID/PIPD maximums in the region
Light grey signifies only treatment difference magnitude exceeded the PID/PIPD maximum in the region